Phospho-APC (S2054) Polyclonal Antibody, 100ul Cell Function Analysis possibly as a result of

possibly as a result of compromised regulatory T cell recruitment

TMEM145 (transmembrane protein 145) is a 493 amino acid protein encoded by a gene mapping to human chromosome 19

This gene is adjacent to a related gene on chromosome 10q23

Belongs to the alkB family

The protein encoded by this gene is an inner protein of the kinetochore

Phospho-APC (S2054) Polyclonal Antibody, 100ul Cell Function Analysis possibly as a result ofAPC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre malignant disease that usually progresses to malignancy. Disease associated mutations tend to be clustered in a small region designated the