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It is a decision aid, not medical advice

But people can get blemishes from flu shots, so there is no direct correlation that B12 causes blemishes. Unfortunately though, theres no way to know beforehand if B12 will cause a breakout

Another possible cause of changes in urine color is excess vitamin B12, which can turn your urine yellow or yellow orange, says Mayo Clinic

Vitamin B12 is an essential nutrient for the body and is needed to protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, support immune function, and maintain a positive mood