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The disulfide in the active site of Trxs can subsequently be reduced by a dedicated reductase, i.e., Trx reductase (TrxR), at the expense of reduced nicotinamide adenin dinucleotide phosphate (NADPH)

The primary outcome measured was the composite of gallbladder or biliary diseases, while secondary outcomes included biliary diseases, biliary cancer, cholecystectomy, cholecystitis, and cholelithiasis

This enhanced mechanism is believed to be the reason for the higher efficacy seen with tirzepatide in promoting weight reduction

It also slows stomach emptying, prolongs meal-related fullness signals, and may reduce reward-driven eating by affecting dopamine pathways

16 if separate vials