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Combination (IGF-1 LR3 + Follistatin-344): +4452% additive rather than synergistic, confirming non-redundant mechanistic pathways

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The main difference between the two is that IGF LR3 is primarily found in mature organisms, while LR2 presents itself more in younger organisms whose bodily systems are still undergoing development

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Alternative and non-mutually exclusive mechanisms may involve favorable effects on basal energy expenditure [57] or on the choice of less energy-rich foods consumed in free-living conditions [58], although these latter hypotheses remain to be validated in clinical studies