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For consumers, this means the first question is not Do I have hypothyroidism? but What kind of thyroid history do I actually have? A person whose hypothyroidism is stable on their thyroid hormone replacement medication may still be a candidate for GLP-1 or GLP-1/GIP treatment, especially if obesity or diabetes is also part of the picture

Even small mistakes here can lead to collateral damage or reduce the medication's benefits

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The 1- and 4-year NNTs were calculated to be 125 and 58 for NNT 3P-MACE , 49 and 25 for NNT EXTENDED , and 20 and 11 for NNT CKM , respectively, indicating a broad benefit of semaglutide beyond the primary endpoint of SELECT