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The agency notes that the peptide is highly susceptible to protein aggregation and the accumulation of peptide-related manufacturing impurities when formulated for injection, which can trigger massive, systemic immune system reactions in human patients

Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

M., Duerschmied, D

Synovial fluid from patients with late-stage OA who were undergoing knee joint replacement had a lower level of oxidoreductases than that from healthy controls 87

D., Gordish-Dressman, H., Hoffman, E