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The studies showing meaningful weight loss with GLP-1 medications arent about raising GLP-1 levelstheyre about activating GLP-1 receptors at a different level than your body produces naturally

5 The recent rise in the demand for GLP-1RAs has led to unexpected drug shortages that have prevented patients who typically use these medications for glycemic management, weight loss, and/or cardiovascular risk reduction from experiencing new challenges in their access to GLP-1RAs

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2) Gradual Dose Escalation Starting low, increasing slowly is almost always the better path to reduce the intensity of side effects