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5 Conclusion In conclusion, the role of metformin in attenuation of weight regain after semaglutide discontinuation needs to be explored in randomized controlled studies in different insulin resistant populations

It also upregulates molecular chaperones and components of the proteostasis network, such as heat shock proteins (HSP60, HSP70) and autophagy-related proteins, facilitating the removal of toxic protein species (75)

doi: 10.1210/clinem/dgaa577

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