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Incretins are endogenous compounds, including GLP-1, that improve glycemic control once released into the circulation via the gut

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Vitamin B12, or cobalamin, is a water-soluble vitamin essential for red blood cell production, nervous system health, DNA synthesis, and energy metabolism

The compound prevents NNMT from wasting nicotinamide (an NAD+ precursor) inside the cell

The gap in the logic is the same one as with methionine: correcting a deficiency is not the same as producing weight loss in someone who is replete