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SIRT5 is a highly efficient protein lysine desuccinylase, and has been shown to participates in carcinogenic process through desuccinylating multiple targets, such as mitochondrial malic enzyme 2 (ME2) [36], pyruvate kinase M2 (PKM2) [37], serine hydroxymethyltransferase 2 (SHMT2) [38], etc

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