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Certain patient groups may face a higher risk of adverse effects or complications with retatrutide and should approach its use with particular caution, or may be advised to avoid it altogether pending further evidence

For the IV regimen, a loading dose of 150 mg/kg in 200 cc is given for 15 minutes, followed by 50 mg/kg in 500 cc over 4 hours and then 100 mg/kg in 1000 cc over 16 hours

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L-carnitine can be synthesized endogenously or taken with the diet, in particularly through meat and dairy products [71], hence its homeostasis reflects the balance between endogenous biosynthesis, absorption from the diet and renal reabsorption [72]