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For someone on a GLP-1 whose appetite is suppressed, this requires planning rather than relying on hunger cues

By activating both GIP and GLP-1 receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning insulin is released primarily when blood glucose levels are elevated

This benefit is particularly useful for individuals engaged in intense physical training

In adults with type 2 diabetes mellitus and chronic kidney disease, treatment regimen should include agents that reduce cardiorenal risk, such as an SGLT2 inhibitor or a GLP-1 receptor agonist

Looking at available treatments for diabetes, insulin has been known and used for more than 100 years and, more recently, peptides such as glucagon-like peptide 1 (GLP-1) have also been used