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10.1016/j.biopha.2021.111585 109 WuY.PiD.ChenY.ZuoQ.ZhouS.OuyangM.et al (2022)

& Tennant, D

10.1371/journal.pone.004794823112875 46 Major TJ, Topless RK, Dalbeth N, et al

A6 cells were maintained in 75 % NCTC-109 supplemented with 10% FCS and 2 mM glutamine at 27C and 5% CO2 as above

In a prespecified time-to-benefit secondary analysis presented at the European Congress on Obesity in 2025 and subsequently published, semaglutide produced a nominally significant reduction in MACE within the first 3 months (HR 0.63, 95% CI 0.410.95) and the first 6 months (HR 0.60, 95% CI 0.440.81), with curve separation visible within approximately 3 weeks of randomization [25], [26]