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Exposure also resulted in eryptosis induction, probably due to the prooxidative effect of lead (2.4-fold higher levels of thiobarbituric acid reactive substances (TBARS) and 32.8% lower GSH/GSSG ratio)

These data reinforce previous reports of iron binding to curcumin and suggest that iron chelation may eventually enable curcumin to reduce both the uptake and toxicity of iron within cells

Underdosing, which may reduce treatment effectiveness

Some of these medications can also interfere with the effectiveness of birth control pills when first started, which is why backup contraception is often advised, Murphy says