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The immunogenicity question is the one to watch

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The semaglutide versus tirzepatide comparison comes down to mechanism and outcomes

Epidemiologic data suggest that a sustained 5 mmHg reduction in systolic blood pressure correlates with approximately 10% lower risk of major cardiovascular events and 7% reduction in all-cause mortality, though it's important to note that cardiovascular outcome trials for tirzepatide are ongoing and definitive cardiovascular benefit has not yet been established

When Wegovy is covered, it almost always sits in the non-preferred tier with strict prior authorization requirements