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Monitoring and Prevention: What to Watch During Treatment Start tirzepatide therapy with a baseline ultrasound if you have risk factors for gallstones (age over 40, female sex, family history, obesity, or rapid weight-loss history)

If youre still in the first month or two, the honest answer might simply be: its too early to judge

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However, there is no established link between GLP-1 or GIP receptor agonists and thyroid cancer in humans, and the relevance of rodent C-cell findings to human thyroid physiology remains questionable due to species differences in C-cell distribution and GLP-1 receptor expression

It increases sex hormone-binding globulin in some contexts while paradoxically reducing it in others, creating unpredictable fluctuations in bioavailable testosterone