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Sources Zhang, L., et al

n = 25)

The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

The docking results suggest that the positively charged guanidinium group of Arg240 interacts strongly with the carboxylate group of L -tyrosine and L -DOPA, whereas the amine group (which is predominantly positively charged at the investigated pH) of the other two substrates is electrostatically repelled (Fig

50mg aligns better with 30-day stability windows at standard dosing