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doi: 10.1016/B978-0-12-805417-8.00004-4 66 ChecaJAranJM

Sexual dysfunction, including impotence (erectile dysfunction) and libido decrease, has been reported in less than 1% of patients receiving extended-release tramadol in clinical trials

Many patients wonder if eating before their weekly injection reduces efficacy, but clinical evidence shows that meal timing does not compromise the medication's 48-week metabolic impact