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For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

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Buteau J, Foisy S, Joly E, Prentki M (2003) Glucagon-like peptide 1 induces pancreatic -cell proliferation via transactivation of the epidermal growth factor receptor

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