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The analysis employed a robust causal inference framework, multiple analytic strategies under an FMA framework, and extensive sensitivity analyses such as principal stratification and E-value estimation

Plasma concentrations decline with age - from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60

Additionally, dietary choices, meal timing, and portion sizes can influence symptom severity

La edad promedio en el inicio del estudio fue de 66 aos y el 68% de los pacientes eran hombres