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Any protective effect likely comes from general cellular resilience rather than direct anti-androgenic action

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Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

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Some research has examined investigated 5-Amino-1MQ effects in diet-induced obesity animal models, extending the Kraus findings to small-molecule inhibitor approaches

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doi:10.3390/nu13061913

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