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For instance, Abolfathi et al

Research indicates that oral L-citrulline supplementation produces more efficient nitric oxide synthesis by bypassing first-pass hepatic metabolism that typically degrades L-arginine before it can reach target tissues [2]

Further study showed that the combinatory treatment with dietary astaxanthin supplementation and heat stress prevented disuse muscle atrophy in the soleus muscle, and this protective effect may be partially due to the higher number of satellite cells (stem cells of the skeletal muscle) [135]

For example, tools like SIAMCAT exemplify how carefully designed ML workflows can uncover disease-associated microbial signatures with predictive value beyond mere statistical associations (203)

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