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Oxidative stress induces ER stress and UPR in LECs under high-sugar conditions, resulting in increased ROS formation and apoptosis 44

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The medications work through different mechanismsWegovy acts on GLP-1 receptors whilst HRT supplements hormonessuggesting minimal potential for direct pharmacological interaction

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GLP-1 receptors are distributed across the hypothalamus, brainstem, reward centers, and memory regions, influencing hunger signals, food preferences, and potentially cognitive function

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