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Diabetics and others with impaired glucose tolerance are highly susceptible to the tissue-damaging effects of advanced protein glycation, a process that occurs when blood sugar reacts with body proteins resulting in various accumulated destructive effects on blood vessels, nerves, and the lens of the eye

A previous study showed that SIRT1 activation inhibits fragmentation and accumulation of prion protein through activation of the autophagy (Wang et al

Analysis of the national multicenter study(1976 to 1985)