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In summary, beneficial Clostridium and their metabolites exert multifaceted protective effects in eight major ADs by regulating gut-immune crosstalk, reinforcing intestinal barrier integrity, and alleviating disease-specific pathological damage, holding great promise as a complementary strategy for clinical immunotherapy

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The glutamine synthetase (GS) and glutamate synthase (GOGAT) cyclic mechanism is largely active when exogenous nitrogen concentrations are limiting, due to the high affinity of GS for ammonium

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