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Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound

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Interestingly, administering 2-AR blockers coupled with CAR-T would also prevent PKA-dependent inhibition of ZAP70 phosphorylation, thereby boosting T cell activation, co-stimulation, and cytotoxicity [123]

Alternative treatments should be considered by pregnant women, nursing mothers, and people with asthma, sulfite allergies, or specific kidney/liver conditions