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En base a la evidencia obtenida en los ensayos clnicos de los ltimos aos, la terapia farmacolgica en la DM2 requiere un cambio del paradigma desde la bsqueda de niveles normales de glucemia, hacia el alcance de efectos protectores o beneficiosos en el sistema cardiovascular o renal

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Among these, enhancing fat metabolism to spare glycogen reserves is particularly interesting, especially in long-duration events

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On this ground the WHO updated its DR-TB treatment guidelines in 2022 (WHO Consolidated Guidelines on Tuberculosis, 2024), recommending the 6-month BPaL-M regimen for MDR/Rifampicin-Resistant (RR)-TB in patients unexposed to bedaquiline, pretomanid, or linezolid (Johnson et al., 2024)