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This gives rise to a vicious cycle: hepcidin levels in patients with -thalassemia are frequently too low, thereby triggering excessive iron absorption in the intestines and the mobilization of iron in macrophages, ultimately leading to iron overload in various organs, including the heart (5254)

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For instance, administration of FMT from ESKD patients to renal injured germ-free mice or antibiotic-treated rats resulted in an increased production of serum uraemic toxins, exacerbated renal fibrosis and oxidative stress, while control models with FMTs from healthy donors did not show these effects (Wang et al., 2020)

Therefore, a variety of experimental studies and calculations consistently suggest a short half life in the 23 hour range