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Since poor blood supply is one of the primary reasons ligament healing is slow, this vascular mechanism is considered particularly relevant to the ligament repair application

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Second, OS activates the polyol pathway, depleting NADPH reserves and reducing glutathione levels, leaving nerves vulnerable to lipid peroxidationa process evidenced by 3-fold higher levels of 4-HNE in sural nerve biopsies from diabetic patients with neuropathy compared to controls (Chong and Souayah, 2025)