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On the molecular level, although core myelin proteins such as PLP, MBP, and CNP are conserved, detailed proteomic analyses reveal marked differences: for instance, proteins like PMP2 are specific to human CNS myelin, whereas tetraspanin-2 (TSPAN2) and connexin-29 (CX29/ GJC3) were restricted to mouse myelin (Gargareta et al., 2022)

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Because vitamin B12 has action at the cellular level and is in charge of multiple pathways where a deficiency may lead to the subjective feeling of fatigue or low energy