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Colonic melanosis was first reported in literature about 140 years ago by Cruveilhier, who described it in a patient with chronic diarrhea in which "the inner surface of the large intestine was black as" China ink "

There is no consensus on the tolerable upper intake level of vitamin B12 or if too much is toxic

19 Along with regulating pigmentation, MC1R signalling is a key mediator of DNA repair and reactive oxygen species regulation following UVinduced damage