Ambrisentan 304 MIC(90)s 0

MIC(90)s 0

3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

4-DPCA was used at 10 µM final concentration in vitro and in cellular assays

DUN09716 (0-100 μM) shows strong inhibition selectivity in NSCLC cells with IC50s ranging from 39

951441-04-6

Ambrisentan 304 MIC(90)s 0Ambrisentan, also known as BSF 208075 and LU 208075, is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6 minute walk distance) compared with placebo in two double blind, multicenter trials (ARIES 1 and ARIES 2). Ambrisentan was approved by