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When Depression Is the Primary Complaint If depression is the dominant symptom: Evaluate histamine status before escalating antidepressants Assess methylation balance Address inflammatory drivers Treating histamine imbalance often improves mood, cognition, and sleep without increasing psychiatric medication burden

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It might also help with digestion, adding extra benefits for some users

However, oral wegovy is contraindicated if you have a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

What matters most is that the consultation is clinically appropriate, the medication is prescribed by a qualified UK prescriber, and delivery is handled correctly through a cold-chain process