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While the absolute risk remains low, researchers suggest the findings should guide discussions between doctors and patients about the benefits and risks of treatment with Ozempic

For people living with type 2 diabetes, the benefits go beyond weight loss

The bupropion trazodone serotonin syndrome risk is considered low to moderate, yet real, because trazodone increases serotonergic tone

Since this study did not employ a crossover design and the information on dosing time relied on patients self-report and compliance, a randomized, double-blind, placebo-controlled, crossover trial by the same research group in 2016 aimed to provide more solid evidence (98)

In addition, further subgroup analyses for different ages and ADR also yielded negative results (Additional file 1: Fig S56)