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IMAC is a method to purify a protein with an affinity for metal ions, such as Co 2+ , Ni 2+ , Cu 2+ , or Zn 2+ , immobilized on a matrix (Yang et al ., 1998)

It's something like 27 more gallbladder-related events per every 10,000 patients treated per year, so it's a pretty small absolute risk. He added that the incidence of gallbladder events often increases after weight loss in general, but some studies suggest that GLP-1 drugs slow down gallbladder motility which could create a sludge that leads to gallstones (8)

Frontiers in Pharmacology, 2017, 8: 904

Yong Shi, Karolinska Institutet (KI), Sweden Updates Copyright 2021 Wu, Li, Liu and Huang

[DOI] [PubMed] [Google Scholar] [206].Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M (2002)