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Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling

Enclomiphene is generally well tolerated with minimal side effects occurring rarely, such as headache (in less than 4% of patients), nausea (less than 3%), and joint pain (less than 2%)

Pizzimenti, S., Toaldo, C., Pettazzoni, P., Dianzani, M

DOI: 10.3389/fimmu.2024.1338745 50

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