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It has been reported that there was an increased abundance of genus Bacteroides , and genus Erysipelatoclostridium and a decreased abundance of phylum Cyanobacteria , phylum Saccharibacteria , genus Bacteroidales S24-7 group , genus Chloroplast (c) , genus Lachnospiraceae NK4A136 group , genus Prevotella 9 , and genus Candidatus Saccharimonas in the tissues of brain tumour patients compared to the controls [189]

Other important factors include: Duration of diabetes : Longer disease duration is associated with greater beta-cell dysfunction, which may reduce the incretin-based response to DPP-4 inhibition Residual beta-cell function : As DPP-4 inhibitors rely on stimulating endogenous insulin secretion, patients with significantly impaired beta-cell reserve may respond less well Adherence to treatment : Consistent daily dosing is essential

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