Acipimox triol WP1130 was administered through IP

WP1130 was administered through IP injection at 40 mg/kg every other day

1-dioxo-2H-1λ⁶

Pirfenidone (PFD) reduces the protein levels of the matrix metalloproteinase (MMP)-11

InChi: InChI=1S/C27H23F3N6O/c1-15(2)25-35-22(23-24(31)32-12-13-36(23)25)20-10-11-21(19-9-4-3-8-18(19)20)34-26(37)33-17-7-5-6-16(14-17)27(28

CAS Number: 1207258-55-6

Acipimox triol WP1130 was administered through IPAcipimox, also known as Olbemox and K 9321, is hormone sensitive lipase inhibitor. Acipimox treatment resulted in a robust elevation in expression of nuclear encoded mitochondrial gene sets and a mitonuclear protein imbalance, which may indicate activation of the mitochondrial unfolded protein response. Further studies in C2C12 myotubes confirmed a direct effect of acipimox on NAD(+) levels, mitonuclear protein imbalance, and mitochondrial oxidative