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Dont use the medication in patients who use certain medications such as tamoxifen (increases chance of retinal toxicity) or patients who use drugs that prolong the QT interval (increases the chance of heart rhythm problems)

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If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression

It has been studied extensively in colitis models, where it reduces intestinal inflammation through the same NF-kB suppression mechanism that benefits skin inflammation