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"There are two types of pigment (melanin) produced by these melanocytes, eumelanin, which creates dark hair pigments that make brown or black hair, and pheomelanin, which produces red or yellow hues." The many varieties of hair color are created with different proportions of eumelanin and pheomelanin, which are determined by genetics, she explains

In addition, the concentrations of proinflammatory cytokines, such as IL-17 and TNF-, were significantly increased, whereas those of several anti-inflammatory cytokines and chemokines, such as IL-1ra, IL-7, and MIP-1, were distinctly reduced in the plasma of MS patients compared with those in healthy subjects

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This hyperexcitability is driven by changes in ion channel expression and function following nerve damage (Tsantoulas and McMahon, 2014