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4.5.2 Early pregnancy exposure: risk characterization under limited data Existing registry, cohort, and systematic-review data have not identified a stable pattern of major structural malformations after brief early-pregnancy exposure to GLP-1RAs, but the exposed human evidence base remains limited and heterogeneous

Ongoing drug trials are seeking to demonstrate, in the next several years, if GLP-1 drugs are effective at treating and/or reducing rates of obstructive sleep apnea, heart failure, NASH (nonalcoholic steatohepatitis) and MASH (metabolic dysfunction-associated steatohepatitis), chronic kidney disease, peripheral arterial disease, joint replacement, osteoarthritis, Alzheimers, cancer and all-cause mortality

Clinical trials discovered that individuals on this drug can shed as much as 20% of their weight

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271 : 985991 Maltby N, Broe GA, Creasey H, Jorm AF, Christensen H, Brooks WS