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There have been several cardiovascular outcomes trials (CVOTs) involving GLP-1RAs, which have supported the overall cardiovascular benefits of these drugs

Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice

doi: 10.1016/j.xcrm.2024.101706 143 WiseDRThompsonCB

412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1