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however, it is hypothesised based largely on preclinical and early clinical data that glucagon receptor agonism, in the context of GLP-1 co-stimulation, may increase energy expenditure and promote fat breakdown (lipolysis), potentially amplifying weight loss beyond what is achievable with dual agonists alone

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Adverse events and GI side effects, though not serious, prompted a significant number of people in the studies to stop taking semaglutide

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