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Notably, this sequence contains non-proteinogenic residues including alpha-aminoisobutyric acid (Aib) and D-amino acids (D-2-naphthylalanine and D-phenylalanine), which are deliberately incorporated to enhance metabolic stability and receptor-binding selectivity

STRING v11: Proteinprotein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

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This shows that the effects induced by the intervention could either be due to the direct effects of the polyphenols or indirectly by modifying the configuration of the gut microbiota

These include midodrine, an alpha-1 adrenergic agonist approved by the FDA for symptomatic orthostatic hypotension that induces vasoconstriction to increase peripheral resistance and standing blood pressure