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[16] MT1 receptors are primarily associated with sleep induction and maintenance, while MT2 receptors play a more significant role in circadian rhythm regulation and phase shifting

The reaction of NAD synthesis is ATP-dependent enzymatic amidation of deamido-NAD+ catalyzed by NAD+ synthetase [9,14]

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For all included studies, the intervention (retatrutide or LY3437943) was administered subcutaneously once weekly in multiple ascending doses, except in one single-dose pharmacokinetic study