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The second part of the strategy was to find the optimal combination of a fatty acid with high albumin affinity, attached to GLP-1 via a water compatible chemical linker, to ensure that the derivatized peptide had high GLP-1R potency in the presence of albumin

The mechanisms are not fully understood but may involve delayed gastric emptying, activation of the area postrema in the central nervous system, changes in nutrient absorption, and altered intestinal motility [116,117,118]

But Shin says whats really needed is information from randomized, double-blinded studies, in which participants are followed forward in time and given either a drug or a placebo

Armed with data from two successful Phase III trials, the company plans to apply for approval from the Food and Drug Administration, with a decision on the drug expected next year