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Topical Formulations Cyclodextrins are used in topical formulations such as gels and creams to stabilize active ingredients, enhance permeation for topical formulations, and to control/modify their release (Table 6)

Retained Gastric Contents Studies Multiple studies have consistently demonstrated increased rates of retained gastric contents in patients taking GLP-1 RAs, though with variable magnitude depending on study design and patient populations [32]

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Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects