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Additionally, tirzepatide was designed to bind to the GIPR with an affinity 5-fold stronger than that for the GLP1R, resulting in greater potency and selectivity in engaging the GIPR over the GLP1R

GIP may add further support for insulin response, metabolism, and how the body manages fat

Furthermore, GIPR antagonists increase metabolism in obese mice, and when combined with GLP1RAs, both GIPR agonists and antagonists have beneficial therapeutic effects