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The LEADER trial enrolled patients with T2DM and high cardiovascular risk, defined as established CVD (81%) or age 60 years with at least one risk factor, and showed that liraglutide significantly reduced the incidence of 3-point major adverse cardiovascular events (MACE) (i.e., CV death, non-fatal myocardial infarction, non-fatal stroke) by 13% compared to placebo (HR 0.87

Semaglutide has been structurally modified to resist DPP-4 degradation and to bind to albumin, resulting in a significantly extended half-life of approximately one week

A meta-analysis of RCTs also showed that this combination (CagriSema) resulted in significantly greater weight loss compared to semaglutide alone 8

Patient-reported outcomes including symptom severity and quality of life measures inform clinical decision-making for Houston residents